DetermInants of Antimicrobial use aNd de-escalAtion in critical care

The Diana study is a multicenter, international, prospective, observational cohort study endorsed by the ESICM (European Society of Intensive Care Medicine).

We will study critically ill patients receiving empirical antibiotic therapy for suspected or confirmed infections at the Intensive Care Unit (ICU).

The primary objective of the study is to describe the empirical antibiotic therapy for infections at the ICU and to describe the rate of de-escalation as well as the associated outcome (mortality, length of stay on ICU, hospital length of stay, infection relapse, subsequent infection).

Patient inclusion is now closed, and participation is no longer possible.

The database has been locked and data analysis is ongoing. The main results will be presented in due time.

Please contact us if you have any questions.